For informational and research purposes only. Not medical advice. Content is aggregated from public sources. Always consult a qualified healthcare provider.

TB-500

Healing

Also known as: Thymosin Beta-4, Tβ4, TB500

TB-500 is a research compound not approved for human use. This profile is for informational purposes only.

Overview

TB-500 is a synthetic fragment of Thymosin Beta-4, an endogenous protein involved in cell migration, tissue repair, and inflammation regulation. It has shown significant healing properties in preclinical models across muscle, tendon, ligament, and cardiac tissue.

Research Summary

TB-500 promotes healing by upregulating actin, which drives cell migration to injury sites. Animal studies show accelerated repair of muscle tears, tendon injuries, and corneal wounds. It also demonstrates anti-inflammatory properties and has been studied for cardiac tissue repair following ischemic injury.

Dosing Range

low

2mg

moderate

5mg

high

10mg

Units: mg · Frequency: twice weekly (loading), weekly (maintenance)

Dosing ranges are aggregated from preclinical research and community protocols. Not medical dosing guidance.

Administration Routes

Subcutaneous injectionIntramuscular injection

Reconstitution Notes

Reconstitute with bacteriostatic water. Standard dilution: 2mg per 1mL BAC water. Stable for 28 days refrigerated.
Step-by-step reconstitution guide →

Reported Side Effects

  • Head rush / lightheadedness (transient)
  • Lethargy at higher doses
  • Injection site discomfort
  • Nausea (rare)

Research Papers

Thymosin Beta-4 accelerates wound healing
FASEB Journal2002
TB-500 promotes cardiac repair after myocardial infarction
Nature2011

Community Experiences

Aggregated from public forums. Anecdotal — not clinical evidence.

r/Peptides

Community protocols combining TB-500 with BPC-157 for injury recovery.

View original thread

Overview

TB-500 is a synthetic version of a region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide present in nearly all human and animal cells. The active region responsible for most healing effects is the actin-binding domain, which TB-500 replicates.

Mechanism

TB-500 works primarily by upregulating and sequestering actin — the protein responsible for cell structure and movement. This drives:

  • Faster migration of repair cells (fibroblasts, keratinocytes) to injury sites
  • Promotion of new blood vessel formation (angiogenesis)
  • Down-regulation of pro-inflammatory cytokines

Common Stacks

TB-500 is most commonly stacked with BPC-157. The two appear complementary: BPC-157 works locally at the injury site while TB-500 has more systemic effects.

Typical loading protocol:

  • Weeks 1–4: 5mg TB-500 + 500mcg BPC-157, twice weekly
  • Weeks 5+: 2mg TB-500 + 250mcg BPC-157, weekly maintenance

Research Notes

Most evidence comes from rodent models. Human clinical data on TB-500 specifically is limited — the majority of human thymosin beta-4 research has been conducted with the full Tβ4 molecule (RegeneRx's RGN-352).

Want to calculate your dose? Use the dosing calculator →