For informational and research purposes only. Not medical advice. Content is aggregated from public sources. Always consult a qualified healthcare provider.

Ipamorelin

Performance

Also known as: NNC 26-0161, Ipamorelin acetate

Ipamorelin is a research compound not approved for human use. For informational purposes only.

Overview

Ipamorelin is a selective growth hormone secretagogue (GHS) and ghrelin receptor agonist. It stimulates GH release with high selectivity — minimal cortisol or prolactin elevation compared to older GHRPs. Widely used in research protocols for body composition, sleep quality, and recovery.

Research Summary

Ipamorelin selectively stimulates GH release via the ghrelin receptor (GHS-R1a) without meaningfully elevating cortisol, aldosterone, or prolactin. Animal studies show dose-dependent GH pulses with rapid clearance. Commonly combined with CJC-1295 to create synergistic GH release — the GHRH+GHRP combination amplifies pulse amplitude significantly over either compound alone.

Dosing Range

low

100mcg

moderate

200mcg

high

300mcg

Units: mcg · Frequency: 1–3x daily (typically pre-sleep and/or pre-workout)

Dosing ranges are aggregated from preclinical research and community protocols. Not medical dosing guidance.

Administration Routes

Subcutaneous injectionIntramuscular injection

Reconstitution Notes

Reconstitute with bacteriostatic water. Common concentration: 2mg per 2mL BAC water (1mcg/µL). Stable 28 days refrigerated.
Step-by-step reconstitution guide →

Reported Side Effects

  • Water retention (mild)
  • Tingling / numbness in extremities
  • Increased appetite
  • Headache (transient)
  • Flushing

Research Papers

Ipamorelin — a new growth hormone-releasing peptide
European Journal of Endocrinology1998

Community Experiences

Aggregated from public forums. Anecdotal — not clinical evidence.

r/Peptides

Community protocols using ipamorelin with CJC-1295 for GH optimization.

View original thread

Overview

Ipamorelin was developed in the late 1990s by Novo Nordisk as one of the cleanest GHRP compounds. Its primary advantage over older GHRPs (GHRP-2, GHRP-6) is high selectivity — it does not significantly raise cortisol or prolactin at research doses.

The CJC-1295 + Ipamorelin Stack

This is one of the most commonly studied peptide combinations. The mechanism is synergistic:

  • CJC-1295 (GHRH analog): Elevates the baseline GH pulse amplitude
  • Ipamorelin (GHRP): Triggers the GH pulse timing

Together they produce GH pulses significantly larger than either alone. Typical combined dosing: 100mcg CJC-1295 + 100–200mcg Ipamorelin administered 30 minutes before sleep.

Selectivity Profile

| Hormone | GHRP-6 | GHRP-2 | Ipamorelin | |---------|--------|--------|------------| | GH | ↑↑↑ | ↑↑↑ | ↑↑↑ | | Cortisol | ↑↑ | ↑↑ | ↔ | | Prolactin | ↑ | ↑↑ | ↔ | | Appetite | ↑↑↑ | ↑↑ | ↑ |

Ipamorelin's selectivity makes it the preferred GHRP in most current research protocols.

Want to calculate your dose? Use the dosing calculator →