GHRP-6
Also known as: Growth Hormone Releasing Peptide-6, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
GHRP-6 is a research compound not approved for human use by the FDA. For research and informational purposes only.
Overview
GHRP-6 is a first-generation synthetic hexapeptide GH secretagogue that strongly stimulates pituitary GH release via ghrelin receptor activation. It is one of the oldest and most well-studied GHRPs, with a large body of research spanning more than three decades. GHRP-6 produces significant GH pulses but is notable for powerfully stimulating appetite — a side effect that can be beneficial for those in a caloric deficit or disadvantageous for those managing body composition.
Research Summary
Human studies confirm GHRP-6 robustly elevates GH within 15–30 minutes of injection, with effects diminishing toward baseline within 2–3 hours. Chronic use increases baseline IGF-1. Research also indicates mild stimulation of cortisol and prolactin, particularly at higher doses. Animal models have shown potential cardioprotective, hepatoprotective, and muscle-sparing effects, though human equivalents are not established.
Dosing Range
low
100mcg
moderate
200mcg
high
300mcg
Units: mcg · Frequency: 1–3 times daily, on an empty stomach
Dosing ranges are aggregated from preclinical research and community protocols. Not medical dosing guidance.
Administration Routes
Reconstitution Notes
Reconstitute with 2 mL bacteriostatic water per 5 mg vial. Refrigerate at 2–8°C after reconstitution. Use within 30 days.Step-by-step reconstitution guide →
Supplies you'll need
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Reported Side Effects
- Strong increase in appetite (most common and notable)
- Elevated cortisol and prolactin at higher doses
- Water retention / bloating
- Fatigue at high doses
- Injection site irritation
- Hypoglycemia-like sensation shortly after injection (rare)
Research Papers
3 peer-reviewed sourcesCommunity Experiences
Aggregated from public forums. Anecdotal — not clinical evidence.
Community experiences emphasize appetite increase as the defining characteristic. Many use it during bulking phases or caloric deficits to manage hunger. Others prefer GHRP-2 for body composition phases.
View original threadOlder community threads document protocols combining GHRP-6 with Mod GRF 1-29 for synergistic GH pulses. Frequency and timing guidelines widely discussed.
View original threadWant to calculate your dose? Use the dosing calculator →