Epithalon
Anti-AgingAlso known as: Epitalon, Epithalone, Tetrapeptide Ala-Glu-Asp-Gly
Epithalon is a research compound not approved for human use by the FDA. The bulk of clinical data comes from Russian research groups. For informational purposes only.
Overview
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from Epithalamin, a polypeptide extract of the pineal gland. It has been studied since the 1980s by Russian researchers, primarily Vladimir Khavinson, for its ability to activate telomerase and extend telomere length — one of the few compounds with direct evidence of telomere elongation in human cells.
Research Summary
Epithalon activates telomerase (hTERT), the enzyme responsible for maintaining telomere length. In vitro and animal studies show telomere elongation, extended cell lifespan, and reduced DNA oxidation. Russian clinical studies in aging populations report improved melatonin rhythms, immune function, and reduced cancer incidence over multi-year follow-up.
Dosing Range
low
5mg
moderate
10mg
high
20mg
Units: mg · Frequency: daily for 10–20 day cycles, 1–2x per year
Dosing ranges are aggregated from preclinical research and community protocols. Not medical dosing guidance.
Administration Routes
Reconstitution Notes
Reconstitute with bacteriostatic water. Common concentration: 10mg per 2mL. Store at 2–8°C. Stable 28 days reconstituted.Step-by-step reconstitution guide →
Reported Side Effects
- Generally very well-tolerated
- Injection site discomfort
- Vivid dreams (commonly reported)
- Improved sleep depth (often reported as benefit)
Research Papers
Community Experiences
Aggregated from public forums. Anecdotal — not clinical evidence.
Longevity community logs on Epithalon cycle protocols and subjective effects.
View original threadOverview
Epithalon is arguably the most significant peptide in longevity research from a telomere perspective. While much of the data originates from Russian institutes (primarily Khavinson's group at the St. Petersburg Institute of Bioregulation), multiple independent in vitro studies have confirmed its telomerase-activating properties.
Telomere Biology
Telomeres are protective caps on chromosome ends that shorten with each cell division. When they reach a critical length, cells enter senescence or apoptosis. Telomerase normally maintains telomere length in germ cells and stem cells but is suppressed in most somatic cells.
Epithalon appears to re-activate hTERT (the catalytic subunit of telomerase) in somatic cells, potentially allowing them to replicate beyond their normal Hayflick limit.
Pineal Gland Connection
Epithalon is derived from Epithalamin, a pineal polypeptide. The pineal gland's role in aging via melatonin regulation is well-established. Multiple Epithalon studies report normalization of melatonin circadian rhythms — which may account for the sleep improvement many users report.
Cycling Protocol
Most research protocols use Epithalon in cycles (10–20 days on, several months off) rather than continuous use. The rationale is to avoid potential feedback suppression of endogenous telomerase regulation.
Want to calculate your dose? Use the dosing calculator →