BPC-157
HealingAlso known as: Body Protection Compound, PL 14736, Pentadecapeptide BPC 157
BPC-157 has not been approved by the FDA for human use. All studies cited are preclinical (animal models). This information is aggregated from public research and community sources and is not medical advice.
Overview
BPC-157 is a synthetic pentadecapeptide derived from a protective protein found in gastric juice. It has been extensively studied in preclinical models for its role in tissue repair, gastroprotection, and tendon/ligament healing.
Research Summary
Preclinical rodent studies have demonstrated accelerated healing of tendons, ligaments, muscles, and intestinal tissue. BPC-157 appears to upregulate growth hormone receptors in tendon fibroblasts and modulate nitric oxide (NO) pathways. It has shown gastroprotective effects across numerous animal studies, including protection from NSAID-induced gut damage.
Dosing Range
low
200mcg
moderate
500mcg
high
1000mcg
Units: mcg · Frequency: once or twice daily
Dosing ranges are aggregated from preclinical research and community protocols. Not medical dosing guidance.
Administration Routes
Reconstitution Notes
Reconstitute with 2 mL bacteriostatic water per 5 mg vial. Store reconstituted peptide refrigerated at 2–8°C. Use within 30 days. Protect from light.Step-by-step reconstitution guide →
Reported Side Effects
- Nausea (rare, typically at higher doses)
- Dizziness (reported anecdotally)
- Injection site redness or irritation
- Lightheadedness shortly after injection (uncommon)
Research Papers
Community Experiences
Aggregated from public forums. Anecdotal — not clinical evidence.
Community thread discussing 12-week BPC-157 protocols for Achilles tendon recovery. Many users report meaningful improvement in pain and function within 4–8 weeks.
View original threadUser log documenting 8-week BPC-157 oral protocol for IBS-type gut inflammation. Notes significant reduction in bloating and discomfort by week 4.
View original threadDiscussion thread about BPC-157 for mood stabilization and anxiety. Mixed reports — some note calmness; others see no effect on mood at standard doses.
View original threadMechanism of Action
BPC-157 is believed to work through several pathways:
- Nitric oxide modulation: Influences the NO system, which plays a key role in blood vessel dilation and tissue repair signaling.
- Growth hormone receptor upregulation: Increases GH receptor expression in tendon fibroblasts, accelerating connective tissue repair.
- Angiogenesis: Promotes the formation of new blood vessels in injured tissue.
- Gut-brain axis: Modulates dopamine and serotonin pathways, which may explain observations around mood and gut motility.
Common Use Cases in Research
BPC-157 research broadly falls into two categories:
Musculoskeletal healing: Tendons (Achilles, rotator cuff), ligaments, muscle tears. Protocols typically involve subcutaneous or intramuscular injection near the injury site.
Gut healing: Inflammatory bowel conditions, NSAID-induced gut damage, leaky gut. Oral administration is most common in gut-focused protocols, though systemic injection is also used.
Protocol Notes
Most preclinical protocols use dosing between 1–10 mcg/kg in rodents. Community human protocols typically range from 200–500 mcg per injection, once or twice daily, for 4–12 weeks. Cycling is common but not universally agreed upon.
BPC-157 is frequently stacked with TB-500 for soft tissue injuries, as the two peptides are thought to have complementary mechanisms.
Want to calculate your dose? Use the dosing calculator →